Author Name
Alalor Christian Arerusuoghene, Okafo Sinodukoo Eziuzo, Avbunudiogba John Afokoghene, Atimah Charles Onajite.
Journal Name
International Journal of Biosciences | IJB
Publisher Name
International Network For Natural Sciences | INNSpub
Abstract
Dissolution is an important preceding step for the absorption of
drugs in class II of the Biopharma ceutics Classification System (BCS)
resulting in poor bioavailability. This current study was directed at
determining the outcome of in situ micronization technique on
the dissolution and solubility profiles of paracetamol. Six formulations
of paracetamol microcrystals were produced by the solvent change method
using HPMC and PVP K30 as stabilizing agents. The solubility,
percentage drug content, and dissolution patterns of the produced
microcrystals were all tested. The study disclosed that paracetamol
solubility was increased up to 5-fold in the PVP K30 stabilized
paracetamol microcrystal and a 4.5-fold increase for HPMC stabilized
paracetamol microcrystal. The time course of dissolution was improved
significantly from 0.6%/min for plain paracetamol to 1.1%/min and
1.2%/min for HPMC and PVP K30 stabilized paracetamol microcrystal
respectively. Formulation P6, with 0.08 g of PVP K30 as stabilizing
agents and an anti-solvent to solvent ratio of 1:6 was the optimized
formulation having a 5-fold solubility increase, 98.3% content of active
and 95.32% drug release in 60 minutes. The solvent change strategy of
the in situ micronization technique could be used for the augmentation of solubility and dissolution of paracetamol. Check out more by following the link Solubility and dissolution optimization of paracetamol using in situ micronization by solvent change method
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