Climate Shapes Manganese-Rich Soils in Côte d’Ivoire | JBES 2020

Krogba Yves Nangah, Yao Kouman Nestor Kouakou,  Kouamé Antoine N’Guessan, and Albert Yao-Kouame, from the institute of the Côte d’Ivoire. Wrote a research article about, Climate Shapes Manganese-Rich Soils in Côte d’Ivoire. Entitle, Chemical variability of climate sequence of manganesiferous soil derived from volcano-sedimentary materials in Côte d’Ivoire. This research paper published by the Journal of Biodiversity and Environmental Sciences |JBES. an open access scholarly research journal on Environmental Sciences. under the affiliation of the International Network For Natural Sciences| INNSpub. an open access multidisciplinary research journal publisher

Abstract

Knowledge of limiting factors is an important prerequisite for ensuring efficient agricultural production, agronomically, economically and environmentally. The objective of this study is to determine the basic physicochemical properties of manganiferous soils derived from volcano-sedimentary material under different climatic facets. Three sites on different climatic facets were prospected. An analysis of soil samples was carried out in order to determine the physicochemical parameters (water pH, exchangeable bases, CEC, organic matter, phosphorus). The results show that soils are acidic with pH <5.5. The available phosphorus is better supplied with contents greater than 20mg.kg-1, while the complex is strongly desaturated. This study has highlighted the existence of a marked climatic gradient for organic matter and CEC. These elements follow a decreasing trend, from the North (Savannah zone and Sudanese climate) to the South (forest zone and Attiean climate). The forest area (Guitry) in Attiean Climate remains better enriched in bases compared to the other zones studied. The influence of microclimatic conditions on pedogenesis is important in the individualization of Cambisols. 

Introduction

The soil is the physical and nutritive support of living beings on the surface of the continents, and, as a result, the life support of man. Although the man is in permanent contact with the ground, it is still, in many ways, a black box whose operation is still only partially known. The floors are constantly changing under the combined action of the flow of materials and energy, which, when applied to a parent material, gradually transforming the primary minerals into secondary components (Chadwick and Chorover 2001; Cornu, 2005). These permanent interactions give the soil a large spatial and temporal variability, which is difficult to grasp. This complexity characterizes natural environments and makes their study delicate.

Manganese soils in Côte d'Ivoire are mainly formed on volcano-sedimentary complexes. These volcanosedimentary complexes give rise to browned soils (Cambisols) (Perraud, 1971), and are under different climatic facets. The study of these soils has been limited to morphological characterization and the study of metallic trace elements (Nangah et al., 2019). This does not allow to apprehend the physicochemical environment that reigns in these soils. In addition, they also do not guide decision-making on the prevention of potential risks and the adoption of adequate cropping systems by the majority of the population, which is rural. However, failure to take into account the physico-chemical constraints of soils is detrimental to the exploitation of these, because, certain soil parameters play a preponderant role in the management of plant nutrition, and an adequate supply of nutrients. nutrients depend on their optimization (Troeh and Thompson, 2005). Knowledge of limiting factors is therefore an important prerequisite for ensuring efficient agronomic, economic and environmental agricultural production from reliable diagnoses (Dahnke and Olson 1990, Parent and Dafir 1992).

The objective of this study is to determine the basic physicochemical properties of manganese soils derived from volcano-sedimentary material under different climatic facets.

Reference

Agusto L, Badeau V, Arrouays D, Trichet P, Flot JL, Jolivet C, Merzereau D. 2006. Caractérisation physico-chimique des sols d’une région naturelle à partir d’une compilation de données : exemple des sols du massif forestier landais. Etudes et Gestion des Sols 13(1), 07-22.

Aranda V, Ayora-Canada MJ, Dominguez-Vidal A, M artin-Garcia JM, Calero J, Delgado R, Verdejo T, Gonzalez-Vila FJ. 2011. Effect of soil type and management (organic vs. conventional) on soil organic matter quality in olive groves in a semi-arid environment in Sierra Magina Natural Park (Spain). Geoderma 164, 54-63.

Ben Hassine H, Aloui T, Gallali T, Bouzid T, El Amri S, Ben Hassen R. 2008. Evaluation quantitative et rôle de la matière organique dans les sols cultivés en zones subhumides et semi-arides méditerranéennes de la Tunisie. Agrosolutions 19(2), 4-17.

Bigorre F, Tessier D, Pedro G. 2000. Contribution des argiles et des matières organiques a la rétention de l’eau dans les sols. Signification et rôle fondamental de la capacité d’échange en cations. Comptes Rendus de l ’Académie des Sciences 330, 245-250.

Brady NC, Weil RR. 2002. The nature and properties of soil. Ed. Prentice Hall Inc., New Jersey, 960 p.

Bur T. 2008. Impact anthropique sur les éléments traces métalliques dans les sols agricoles de Midi Pyrénées. Implications en termes de limites et de charges critiques. Thèse de Doctorat, Université de Toulouse, Toulouse 281 p.

Callesen I, Liski J, Raulund-Rasmussen K. 2003. Soil carbon stores in Nordic well-drained forest soils relationships with climate and texture class. Global Change Biology 9, 358-370.

Chauvel A, Lucas Y, Boulet R. 1986. On the genesis of the soil mantle in the region of Manaus, Central Amazonia. Experientia 43(3), 285-299.

Dai W, Huang Y. 2006. Relation of soil organic matter concentration to climate and altitude in zonal soils of China. Catena 65, 87-94.

Dorel M, Lombard K, Oliver R. 2005. Azote minéralisable et statut organique des Andosols de Guadeloupe. Etude et Gestion des Sols 12(4), 267-280.

Duchaufour P. 1977. Pédogenèse et classification. Eds. Masson, Paris 477 p.

Elbering B, Touré A, Rasmussen K. 2003. Changes in soil organic matter following groundnut-millet cropping at three locations in semi-arid Senegal, West Africa. Agriculture, Ecosystems and Environment 96, 37-47.

Ganuza A, Almendros G. 2003. Organic carbon storage in soils of the Basque Country (Spain): the effect of climate, vegetation type and edaphic variables. Biology and Fertility of soils 37, 154-162.

Genot V, Colinet G, Brahy V, Bock L. 2009. L’état de fertilité des terres agricoles et forestières en région wallone (adapté au chapitre 4-sol1) de « l’état de l’environnement wallon 2006-2007 ». Biotechnologie, Agronomie, Société et Environnement 13, 121-138.

Heviaa GG, Bushiazzoa DE, Heppera EN. 2003. Organic matter in size fractions of soils of the semiarid Argentina. Effect of climate, soil texture and management. Geoderma 116, 265-277.

Jandl R, Smidt S, Mutsch F, Fürst A, Zechmeister H, Bauer H, Dirnbock T. 2012. Acidification and Nitrogen Eutrophication of Austrian Forest Soils. Applied and Environmental Soil Science 2012, 1-9.

Landon JR. 1991. Booker tropical soil manual. A handbook for soil survey and agricultural land evaluation in the tropics and subtropics. Eds. Longman, Oxon 474 p.

Lemenih M, Itanna F. 2004. Soil carbon stocks and turnovers in various vegetation types and arable lands along an elevation gradient in Southern Ethiopia. Geoderma, 123, 177-188.

Liu Z, Shao M, Wang Y. 2011. Effect of environmental factors on regional soil organic carbon stocks across the Loess Plateau region, China. Agriculture, Ecosystems and Environment 142, 184-194.

Lucas Y, Luizao FJ, Chauvel A, Rouiller J, Nahon D. 1993. The relation between biological activity of the rain forest and mineral composition of soils. Science 260, 521-523.

Menzies NW. 2003. Toxic elements in acidic soils: chemistry and measurement. In: Rengel Z, Ed. Handbook of soil acidity. Marcel Dekker Inc., New York 267-296.

Mustapha S. 2007. Physico-chemical properties and fertility status of some Haplic Plinthaquults in Bauchi local government of Bauchi state, Nigeria. International Journal of Soil Science 2(4), 314-319.

Maithani K, Arunachalam A, Tripathi RS, Pandey HN. 1998. Nitrogen mineralization as infuenced by climate, soil and vegetation in a subtropical humid forest in northeast India. Forest Ecology and Management 109, 91-101.

Mallouhi N. 1997. Interprétations des analyses du sol et principales caractéristiques de certaines substances organiques et du compost. Coopération Française, Programme d’Appui à la Formation Professionnelle des Agronomes, Faculté des Sciences Agronomiques, Université Nationale du Bénin 20 p.

Marques JJ, Teixeira WG, Schulze DG, Curi N. 2002. Mineralogy of soils with unusually high exchangeable Al from the western Amazon region. Clays Minerals 37, 651-661.

Martin A, Nolin MC. 1991. Etude pédologique du comte de Chambly (Quebec). Volume 2 : Description et classification des séries de sols. Direction Generale de la Recherche, Canada, Contribution n°89-26, 144 p.

Masmoudi S, Rigane H, Ammar E, Medhioub K. 2011. Effets de l’amendement de sols par différents types de composts sur le comportement pédo-géochimique, région d’El hajeb (Sfax, Tunisie). Microbiologie et Hygiène Alimentaire 23, 80-87.

Mbonigaba JJM, Nzeyimana I, Bucacu C, Culot M. 2009. Caractérisation physique, chimique et microbiologique de trois sols acides tropicaux du Rwanda sous jachères naturelles et contrainte à leur productivité. Biotechnologie, Agronomie, Société et Environnement 13(4), 545-558.

Moyin-Jesu EJ. 2008. Soil fertility, chemistry and crop nutrition. Eds. Global-link, Swansea 114 p.

Nangah KY, Yao-Kouamé A, Yao GF, Kouakou YKN, Alui KA et Savane I. 2012. Attributs physico-chimiques et contrainte à la productivité agricole des sols du site manganésifère de Lauzoua (Guitry) en Côte d’Ivoire. Journal of Applied Biosciences 50, 3459-3467.

Nangah KY, Kouakou YKN, Zrau BGF, Yao-Kouame A. 2019. Evaluation of morphological characteristics of manganiferous soils at the scale of the toposequence. JECET; Sec. A Vol. 8. No. 2, 167-176. Quantin P, Dejou J, Tejedor M, Jimenez C. 2007. Sols et paléo-altérites sur roches volcaniques du Cantal (France) : Exemple du Puy Courny. Etude et Gestion des Sols 14(1), 43-62.

Quideau SA, Chadwick QA, Benesi A, Graham RC, Anderson MA. 2001. A direct link between forest vegetation type and soil organic matter composition. Geoderma 104, 41-60.

Romheld V, Kirkby EA. 2010. Research on potassium in agriculture: need and prospects. Plant Soil 335, 155-180.

Sollins P, Homann P, Caldwell BA. 1996. Stabilization and destabilization of soil organic matter: mechanisms and controls. Geoderma 74, 65-105.

Turner BL, Haygarth PM. 2001. Phosphorus solubilization in rewetted soils. Nature 411, 258-259.

Yao-Kouame A. 2008. Caractéristiques chimiques et physicochimiques des sols brunifiés développés sur les formations du complexe volcano sédimentaire de Kanhankro (Toumodi) en moyenne Côte d’Ivoire. Revue CAMES – Série A 7, 17-29.

Yeboua K, Ballo K. 2000. Caractéristiques chimiques du sol sous palmeraie. Cahiers Agricultures 9(1), 73-76.

Yoboue KE, Kouadio KP, Blé LO, et Yao-Kouame A. 2018. Caractéristiques Morphopédologiques et Géochimiques des Sols Brunifiés de Anikro et de Kahankro (Centre-Sud de la Côte d’Ivoire). European Scientific Journal, Vol.14, No.3, 281-300.

Yoboue KE, Yao-Kouame A, Alui KA. 2010. Evolution pédogéochimique et minéralogique au cours de l ’altération des formations du complexe volcano-sédimentaire d’Anikro et de Kahankro (Toumodi) dans le Centre-Sud de la Côte d’Ivoire. European Journal of Scientific Research 40(1), 60-72.

Article source : Chemical variability of climate sequence of manganesiferous soil derived from volcano-sedimentary materials in Côte d’Ivoire

 

 

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Blood Meal Sources of Aedes aegypti in Benin | IJB 2023

Tchibozo Carine,  Yadouleton Anges,  Dramane Gado, Hounkanrin Gildas, Adewumi Praise, and Joest Hanna, from the institute of Benin. Wrote a research article about, Blood Meal Sources of Aedes aegypti in Benin entitled, Origin of the blood meal of the Aedes aegypti mosquito in five localities in Benin. This research paper published by the International Journal of Biosciences | IJB. an open access scholarly research journal on Biosciences. under the affiliation of the International Network For Natural Sciences| INNSpub. an open access multidisciplinary research journal publisher.

Abstract

With the aim of learning about the multiple origins of blood meal sources in Aedes aegypti in Benin, a study was conducted in five localities from the south to the north of the country (Cotonou, Porto-Novo, Calavi, Dassa and kandi) from June 2020 to October 2021 to capture adult populations of A. aegypti. To achieve this objective, BG-Sentinel and Aedes Gravid traps were set daily inside and outside four randomly selected concessions in each of the above-mentioned sites, three times a week for the duration of the study. Populations of blood-feeding A. aegypti mosquitoes were identified using the Polymerase Chain Reaction (PCR) technique. PCR results were confirmed by sequencing to identify the origin of the blood meal. Out of a total of 3,749 mosquitoes collected, Aedes aegypti (79.22%) and Culex quinquefaciatus (20.08%) were the two main species caught. With a total of 2,970 A. aegypti populations, 2,684 (71.7%) were non-blood-fed, compared with 286 (7.6%) blood-fed. For Culex quinquefasciatus, out of 753 populations caught, 733 (19.5%) were non-gorged versus 20 (0.5%) blood-fed. Research into the origin of the blood meal using the PCR technique showed that out of 1019 mosquitoes analyzed, 987 (96.8%) had taken their blood meal from humans. This result was confirmed by sequencing analysis of PCR-positive pools. The anthropophagous nature of A. aegypti confirmed by the sequencing results during this study remains an important clue in the implementation of arbovirus control strategies, particularly against A. aegypti mosquitoes in Benin. 

Introduction

According to the World Health Organization in 2016, several vector-borne diseases are caused by arthropods and the most important are found in subSaharan Africa. The main mosquito general responsible for these diseases are: Anopheles, Aedes and Culex.

Aedes aegypti is the main vector of arboviruses such as dengue, zika, yellow fever and chikungunya. This highly hematophagous domestic mosquito is found in human dwellings and, is present in jars, abandoned cans, from northern to southern Benin throughout the year with risks of spreading dengue fever (Yadouleton et al., 2018). The recent and rapid spread of this mosquito to new geographical areas, including rural environments, means that it is considered a public health problem (WHO, 2016), Moreover, these blood-requiring mosquitoes most often develop a preference for the most available and stable source of blood (Roiberg and Gordon et al., 2005; O'Meara et al., 2020). The preference of mosquito vectors for a specific host for their blood meal undoubtedly affects the mosquitoes' ability to transmit pathogens.

Over the past decade, several cases of arboviruses, notably dengue, have been reported in sub-Saharan Africa, notably in Gabon (Abe et al., 2020), Côte d'Ivoire (Moi et al., 2010), Senegal (Faye et al., 2014) and Burkina-Faso (Ouédraogo et al., 2019), with over 1,500 cases recorded. The preference of mosquito vectors for a specific host for their blood meal surely affects the mosquitoes' ability to transmit pathogens. Consequently, understanding mosquito blood feeding patterns in different environments can help determine which host species can influence the maintenance and epidemic transmission of viruses. With this in mind, this study was carried out in 5 cities in Benin, in order to determine the origin of the blood meal in Aedes aegypti populations.

Article source : Origin of the blood meal of the Aedes aegypti mosquito in five localities in Benin   

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Vulvovaginal Candidiasis in Pregnant Women: Antifungal Susceptibility Insights | IJMM 2025

Kpongbo Etienne Angora,  Matenin Ouattara,  Maurine Aline N’guiachi,  Salifou Koné,  N’drin Effoh, Vincent Djohan, Hervé Eby Menan, and  Adèle Kacou N’douba, from the institute of the Côte d’Ivoire. Wrote a research paper about, Vulvovaginal Candidiasis in Pregnant Women: Antifungal Susceptibility Insights. Entitle, Vulvovaginal candidiasis and antifungal susceptibility patterns among pregnant women at the university hospital of Angré, Abidjan, Côte d’Ivoire. This research paper published by the International journal of Microbiology and Mycology | IJMM.an open access scholarly research journal on Microbiology. under the affiliation of the International Network For Natural Sciences| INNSpub. an open access multidisciplinary research journal publisher.

Abstract

Vulvovaginal candidiasis is a frequent reason for consultation in gynecology. Few studies have been conducted in pregnant women, even though they may be asymptomatic. This study aimed to determine the epidemiological profile of vulvovaginal and antifungal susceptibility patterns among pregnant women at the university teaching hospital of Angré in Abidjan. This cross-sectional study was carried out in the gynecology-obstetrics department of the Angré University Hospital from June to October 2024. Swabs were taken from Pregnant women for mycological analyses. Each sample was examined directly and cultured at 37°C on Sabouraud-Chloramphenicol medium. Candida yeasts were identified using Chromagar Candida medium or Vitek 2. Antifungal susceptibility was determined using the agar diffusion method with discs. Of total of 402 women included, 70 were positive on culture, representing an overall vaginal candidiasis carriage rate of 19.2%. The yeast species identified were Candida albicans (48.1%), Candida krusei (27.8%), Candida tropicalis (12.7%), and Candida glabrata (11.4%). Symptoms such as vaginal discharge, vulvar pruritus, and dyspareunia were statistically linked to Candida carriage (p<0.05). Non-albicans species showed low sensitivity to antifungal agents. Candida krusei was only 68% susceptible to amphotericin B and econazole while Candida tropicalis had low susceptibility. This study showed a relatively high frequency of Candida yeasts in pregnant women. The emergence of non- albicans with less susceptibility to the antifungal drugs highlights the importance of systematically screening pregnant women to better manage vulvovaginal candidiasis. 

Introduction

Vulvovaginal candidiasis is a common reason for gynecological consultations and ranks second after bacterial vaginosis (Sobel, 2007; Konaté et al., 2014). It is estimated that 75% of women experience at least one episode of candidiasis during their lifetime. Among these women, some will have several episodes and around 5 to 8% will develop recurrent vulvovaginal candidiasis (VVC), characterized by at least four confirmed episodes in a year (Achkar and Fries, 2010).

Certain risk factors for VVC are related to sexual activity, recent antibiotic use, immunosuppression attributable to conditions such as poorly controlled HIV infection or diabetes, and pregnancy (Benchellal et al., 2011; Roy et al., 2024). All of these factors contribute to an imbalance in the vaginal flora and the onset of clinical and biological symptoms. Pregnancy is the leading factor promoting CVV due to the hormonal changes observed (Ogouyèmi-Hounto et al., 2014; Blomberg et al., 2023). Candida species are part of the normal flora of the genital tract. In healthy asymptomatic non-pregnant women, these yeasts have been found in 20–30% (Achkar and Fries, 2010; Ghaddar et al., 2020). This situation only poses a danger to the fetus and newborn when the manifestations occur in a context of prematurity or when the prognosis may be lifethreatening (Hong et al., 2014; Duarte et al., 2024). When vaginal candidiasis is not asymptomatic, it can lead to vulvar pruritus and characteristic vaginal discharge. These symptoms may be associated with dysuria, dyspareunia, vaginal dryness, or vulvar burning (Gai et al., 2023).

Untreated, vaginal candidiasis can lead to chorioamnionitis with subsequent miscarriage and prematurity in pregnant women, or congenital infection of inflammatory disease in newborns and pelvic inflammatory disease in infertile women (Ahmad and Khan, 2009; Gedefie et al., 2025).

Vulvovaginal candidiasis is most often caused by the overabundance of an opportunistic pathogenic yeast, Candida albicans (approximately 90%), which is a common member of the vaginal flora (Hussen et al., 2024). Moreover, the emergence of Candida species isolated from clinical samples, indicated that nonalbicans species were considered emerging fungal pathogens in pregnant women (Hussen et al., 2024; Gedefie et al., 2025). These yeasts are commensal species of the skin and gastrointestinal tract, but may be present in the vaginal tract of 20 to 30% of asymptomatic healthy women at any given time. If the balance between the colonizing yeast and the host is temporarily disrupted, Candida can cause infections such as vaginal candidiasis, associated with clinical signs of inflammation (Achkar and Fries, 2010). Candida albicans is known to be resistant to certain antifungal drugs and is generally treated with azole antifungals due to their low toxicity and availability (Dovnik et al., 2015; Whaley et al., 2016).

Vulvovaginal candidiasis is a public health issue due to the morbidity associated with symptoms in women (Bitew and Abebaw, 2018). The prevalence varies from one country to another. In Côte d'Ivoire, some studies in women reported that the prevalence rate was higher than 28% from non-pregnant women (Djohan et al., 2012; Konaté et al., 2014). Few studies have focused on vaginal candidiasis in pregnant women. Therefore, the aim of this study was to determine the prevalence of vulvovaginal and antifungal susceptibility pattern among pregnant women at the university teaching hospital of Angré in Abidjan.

Reference

Achkar JM, Fries BC. 2010. Candida Infections of the Genitourinary Tract. Clinical Microbiology Reviews 23, 253–273. DOI: 10.1128/CMR.00076-09.

Ahmad A, Khan AU. 2009. Prevalence of Candida species and potential risk factors for vulvovaginal candidiasis in Aligarh, India. European Journal of Obstetrics & Gynecology and Reproductive Biology 144, 68–71. DOI: 10.1016/j.ejogrb.2008.12.020.

Benchellal M, Guelzim K, Lemkhente Z, Jamili H, Dehainy M, Rahali-Moussaoui D, El Mellouki W, Sbai Idrissi K, Lmimouni B. 2011. La candidose vulvo-vaginale à l’hôpital militaire d’instruction Mohammed V (Maroc). Journal de Mycologie Médicale 21, 106–112. DOI: 10.1016/j.mycmed.2011.03.003.

Bender RA, Calışkan S, Önal B, Aslancan R, Caliskan E. 2021. Treatment methods for vulvovaginal candidiasis in pregnancy. Journal de Mycologie Médicale 31, 101138. DOI: 10.1016/j.mycmed.2021.101138.

Bitew A, Abebaw Y. 2018. Vulvovaginal candidiasis: species distribution of Candida and their antifungal susceptibility pattern. BMC Women’s Health 18, 94. DOI: 10.1186/s12905-018-0607-z.

Blomberg L, Backman K, Kirjavainen PV, Karvonen AM, Harju M, Keski-Nisula L. 2023. Vulvovaginal yeast infections, gestational diabetes and pregnancy outcome. BMC pregnancy and childbirth 23, 70. DOI: 10.1186/s12884-023-05391-1.

Clinical Laboratory Standards Institute. 2018. Reference method for broth dilution Antifungal susceptibility testing of yeasts; approved Standard CLSI Document M27-A3.

Djohan V, Angora KE, Vanga-Bosson AH, Konaté A, Kassi FK, Yavo W, Kiki-Barro PC, Menan H, Koné M. 2012. Sensibilité in vitro des souches de Candida albicans d’origine vaginale aux antifongiques à Abidjan (Côte d’Ivoire). Journal de Mycologie Médicale 22, 129–133. DOI: 10.1016/j.mycmed.2011.11.005.

Dovnik A, Golle A, Novak D, Arko D, Takac I. 2015. Treatment of vulvovaginal candidiasis: a review of the literature. Acta Dermatovenerologica Alpina, Pannonica, Et Adriatica 24, 5–7. DOI: 10.15570/actaapa.2015.2.

Duarte G, Linhares IM, Kreitchmann R, Tristao A, Da R, Traina E, Canti I, Takimura M, Andrade JQ. 2024. Vulvovaginitis in pregnant women. Revista Brasileira De Ginecologia E Obstetricia 46, e-FPS03. DOI: 10.61622/rbgo/2024FPS03.

Ekwealor CC, Okoro EO, Oyeka CA, Amasiani R. 2023. Vaginal Candidiasis among Pregnant Women in Ebonyi State, South East Nigeria. The Bioscientist Journal 11, 220–230.

Fanou BA, Klotoe JR, Dougnon V, Monteiro A, Koudokpon CH, Loko F. 2022. Prévalence et facteurs associés aux candidoses vulvovaginales chez les femmes admises en consultation à l’Hôpital de Zone de Mènontin (Bénin). The Pan African Medical Journal 42, 215. DOI: 10.11604/pamj.2022.42.215.28984.

Gai S, Wu Q, Zhang H. 2023. The change of inflammatory status and vaginal flora in pregnant women with premature rupture of membranes. Journal of Medical Microbiology 72, 42–47. DOI: 10.1099/jmm.0.001678.

Gedefie A, Shimeles G, Motbainor H, Kassanew B, Genet C. 2025. Vaginal colonization and vertical transmission of Candida species: prevalence and associated factors among pregnant women and their neonates at public health facilities of Northeast Ethiopia. BMC Pregnancy and Childbirth 25, 22. DOI: 10.1186/s12884-024-07103-9.

Ghaddar N, Anastasiadis E, Halimeh R, Ghaddar A, Dhar R, AlFouzan W, Yusef H, El Chaar M. 2020. Prevalence and antifungal susceptibility of Candida albicans causing vaginal discharge among pregnant women in Lebanon. BMC infectious diseases 20, 32. DOI: 10.1186/s12879-019-4736-2.

Hong E, Dixit S, Fidel PL, Bradford J, Fischer G. 2014. Vulvovaginal Candidiasis as a Chronic Disease: Diagnostic Criteria and Definition. Journal of Lower Genital Tract Disease 18, 31–38. DOI: 10.1097/LGT.0b013e318287aced.

Hussen I, Aliyo A, Abbai MK, Dedecha W. 2024. Vaginal candidiasis prevalence, associated factors, and antifungal susceptibility patterns among pregnant women attending antenatal care at bule hora university teaching hospital, Southern Ethiopia. BMC pregnancy and childbirth 24, 619. DOI: 10.1186/s12884-024-06844-x.

Kechia FA, Dohbit JS, Kouotou EA, Iwewe, SY, Dzoyem JP, Mbopuwouo NM, Monamele CG, Moyou SR. 2015. Profil épidémiologique et “tiologique de la Candidose Vulvo-Vaginale chez la Femme Enceinte à Yaoundé (Cameroun). Health Sciences and Disease 16, 6. DOI: 10.5281/hsd.v16i4.594.

Konadu DG, Owusu-Ofori A, Yidana Z, Boadu F, Iddrisu LF, Adu-Gyasi D, Dosoo D, Awuley RL, Owusu-Agyei S, Asante KP. 2019. Prevalence of vulvovaginal candidiasis, bacterial vaginosis and trichomoniasis in pregnant women attending antenatal clinic in the middle belt of Ghana. BMC Pregnancy and Childbirth 19, 341. DOI: 10.1186/s12884-019-2488-z.

Konaté A, Yavo W, Kassi FK, Djohan V, Angora EK, Barro-Kiki PC, Bosson-Vanga H, Soro F, Menan EIH. 2014. Aetiologies and contributing factors of vulvovaginal candidiasis in Abidjan (Cote d’Ivoire). Journal de Mycologie Médicale 24, 93–99. DOI: 10.1016/j.mycmed.2013.11.006.

Konaté-Touré A, Fulgence KK, Paterne AG., Estelle GK, Valérie A B-T, Henriette V-B, Etienne K A, Sebastien AM, Vincent D, Kiki-Barro PC, Hervé EM, William Y. 2024. Etiology and Risk Factors in Patients with Vulvovaginal Candidiasis in Abidjan (Côte d’Ivoire). Journal of Mycology and Infection 29, 155–164. DOI: 10.17966/JMI.2024.29.3.155.

Kone AK, Timbine LG, Diallo MH, Niare-Doumbo S, Soumare I, Ranque S, Kouriba B,  Thera MA. 2025. In Vitro Susceptibility of Candida spp. Isolates to Antifungals from Patients at Charles Mérieux Infectious Disease Centre (CICM) in Bamako, Mali. African Journal of Parasitology Mycology and Entomology 3, 1–14. DOI: 10.35995/ajpme03010001.

Maftei NM, Arbune M, Georgescu CV, Elisei AM, Iancu AV, Tatu AL. 2023. Vulvovaginal Candidiasis in Pregnancy-Between Sensitivity and Resistance to Antimycotics. Journal of Xenobiotics 13, 312–322. DOI: 10.3390/jox13030023.

Nelson MC, Wanyoike W, Margaret MW. 2013. Prevalence of Vaginal Candidiasis and Determination of the Occurrence of Candida Species in Pregnant Women Attending the Antenatal Clinic of Thika District Hospital, Kenya. Open Journal of Medical Microbiology 03, 4–8. DOI: 10.4236/ojmm.2013.34040.

Ogouyèmi-Hounto A, Adisso S, Djamal J, Sanni R, Amangbegnon R, Biokou-Bankole B, Kinde Gazard D, Massougbodji A. 2014. Place des candidoses vulvo-vaginales au cours des infections génitales basses et facteurs de risque associés chez les femmes au Bénin. Journal de Mycologie Médicale 24, 100–105. DOI: 10.1016/j.mycmed.2014.01.003.

Osman-Mohamed A, Suliman MM, Hussain MT, Abdelrahman HM, Ali JM, Ali OK, Omar AM, Makki Mohamed AA. 2022. Prevalence of vulvovaginal candidiasis among pregnant women in Africa: A systematic review and meta-analysis. Journal of Infection in Developing Countries 16, 1243–1251. DOI: 10.3855/jidc.15536.

Rodrigo PD, Georgina R, Érica LS, Luciano T, Josefina JM. 2024. Candida species isolated in female patients of reproductive age with vaginal candidiasis in Gualeguaychú, Entre Ríos, Argentina. Journal of Bacteriology & Mycology: Open Access 12, 98–101. DOI: 10.15406/jbmoa.2024.12.00381.

Roy M, Majumdar T, Ray J. 2024. Vulvovaginal candidiasis in pregnant women attending a tertiary care centre in North-Eastern India. Indian Journal of Medical Microbiology 52, 100738. DOI: 10.1016/j.ijmmb.2024.100738.

Satora M, Grunwald A, Zaremba B, Frankowska K, Zak K, Tarkowski R, Kutak K. 2023. Treatment of Vulvovaginal Candidiasis-An Overview of Guidelines and the Latest Treatment Methods. Journal of Clinical Medicine 12, 5376. DOI: 10.3390/jcm12165376.

Sobel JD. 2007. Vulvovaginal candidosis. Lancet 369, 1961–1971. DOI: 10.1016/S0140-6736(07)60917-9.

Sule-Odu AO, Akadri AA, Oluwole AA, Osinupebi OA, Andu BA, Akiseku AK, Lawal AI. 2020. Vaginal Candida infection in pregnancy and its implications for fetal well-being. African Journal of Reproductive Health 24, 33–40. DOI: 10.29063/ajrh2020/v24i3.4.

Sy O, Diongue K, Ahmed CB, Ba O, Moulay FC, Lo B, Ndiaye D. 2018. Vulvovaginal candidiasis in pregnant women in the Mère et Enfant Hospital center in Nouakchott, Mauritania. Journal de Mycologie Médicale 28, 345–348. DOI: 10.1016/j.mycmed.2018.02.006.

Waikhom SD, Afeke I, Kwawu GS, Mbroh HK, Osei GY, Louis B, Deku JG, Kasu ES, Mensah P, Agede CY, Dodoo C, Asiamah EA, Tampuori J, Korbuvi J, Opintan JA. 2020. Prevalence of vulvovaginal candidiasis among pregnant women in the Ho municipality, Ghana: species identification and antifungal susceptibility of Candida isolates. BMC pregnancy and childbirth 20, 266. DOI: 10.1186/s12884-020-02963-3.

Whaley SG, Berkow EL, Rybak JM, Nishimoto AT, Barker KS, Rogers PD. 2016. Azole Antifungal Resistance in Candida albicans and Emerging Non-albicans Candida Species. Frontiers in Microbiology 7, 2173. DOI: 10.3389/fmicb.2016.02173. 

Article source : Vulvovaginal candidiasis and antifungal susceptibility patterns among pregnant women at the university hospital of Angré, Abidjan, Côte d’Ivoire 

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Ethnobotanical Approaches to Malaria Vector Control | IJB 2025

Eloi Honvoh, Laboratory of Pluridisciplinary Researches of Technical Teaching (LaRPET), Normal High School of Technical Teaching (ENSET) of Lokossa, National University of Sciences, Technologies, Engineering and Mathematics (UNSTIM) of Abomey, P. O. Box 133 Lokossa, Benin. Nazaire Aïzoun, Laboratory of Pluridisciplinary Researches of Technical Teaching (LaRPET), Normal High School of Technical Teaching (ENSET) of Lokossa, National University of Sciences, Technologies, Engineering and Mathematics (UNSTIM) of Abomey, P. O. Box 133 Lokossa, Benin. Arlette Adjatin, Laboratory of Genetics, Biotechnology and Applied Botany (GEBBA), National High School of Applied Biosciences and Biotechnology (ENSBBA) of Dassa-Zoumè, National University of Sciences, Technologies, Engineering and Mathematics (UNSTIM) of Abomey, Benin.Crispus Tossa, Laboratory of Genetics, Biotechnology and Applied Botany (GEBBA), National High School of Applied Biosciences and Biotechnology (ENSBBA) of Dassa-Zoumè, National University of Sciences, Technologies, Engineering and Mathematics (UNSTIM) of Abomey, Benin. Daniel Chougourou, Department of Environment Genius, Polytechnic School of Abomey-Calavi (EPAC), University of Abomey-Calavi (UAC), Cotonou, Benin.Wrote a research paper about, Ethnobotanical Approaches to Malaria Vector Control entitled, Ethnobotanical study for malaria vector control in Couffo department in south-western Republic of Benin, West Africa. This research paper published by the International Journal of Biosciences | IJB. an open access scholarly research journal on Biosciences. under the affiliation of the International Network For Natural Sciences| INNSpub. an open access multidisciplinary research journal publisher.

Abstract

The use of chemical insecticides causes important damages to environment and human health and there is a need to search for alternative solutions. Field surveys were organized from September to November 2023 during the small raining season in districts of Aplahoué, Djakotomey, Dogbo, Klouékanmè, lalo and Toviklin in Couffo department. Two villages were chosen in each of these districts by taking into account the sociodemographic data and the diversity of plants. The locations where these villages were chosen in each district were: Kissamey (Aplahoué), Kokohoué (Djakotomey), Totchangni (Dogbo), Tchikpé (klouekanmey), Doko (Toviklin) and Banigbé (Lalo). Then, investigations were done using ethnobotanical questions. These questions concerned: local names of plants used, the different organs of plants used, the using forms and using modes of these plants in malaria vector control in the villages surveyed. The results showed that more than thirty (30) plants were used by the people of Adja region in malaria vector control. These plants were used as powder applied on the skin of people in order to avoid that the mosquitoes took their meals on their body. The fumigation was the most using mode of cited plant species. Ethnobotanical study is very important in a context of resistance of malaria vector to the main classes of insecticide used in public health. 

 

Introduction

Globally, in 2023, the number of malaria cases was estimated at 263 million, with an incidence of 60.4 cases per 1000 population at risk. This is an increase of 11 million cases from the previous year and a rise in incidence from 58.6 cases per 1000 population at risk in 2022. The WHO African Region continues to carry the heaviest burden of the disease, accounting for an estimated 94% of malaria cases worldwide in 2023. The WHO Eastern Mediterranean Region has experienced a 57% increase in incidence since 2021, risingto 17.9 cases per 1000 population at risk in 2023 (World Malaria Report, 2024).

Globally, in 2023, the number of deaths was estimated at 597 000, with a mortality rate of 13.7 per 100 000. The number of malaria deaths and the mortality rate steadily decreased from 622 000 and 14.9 deaths per 100 000, respectively, in 2020. The WHO African Region continues to carry the heaviest burden of mortality, with 95% of estimated malaria deaths worldwide (World Malaria Report, 2024).

Conventionally, synthetic insecticides organochlorines, carbamates, organophosphates, and pyrethroids temephos, fenthion, malathion, and dichlorodiphenyltrichloroethane (DDT) were expensive, leaving a residual effect, adapting resistance, non-biodegradable, toxicity to non-target organisms (Anyaele and Amusan, 2003). These problems urged the researchers for an expeditious search for new alternatives. Botanical-based insecticides were currently one of the most promising approaches, much research currently being devoted to plant extracts for the development of sustainable botanical insecticides (Liang et al., 2015). Plant extracts contain a mixture of several chemical active ingredients and thus may be able to effectively kill the mosquito through a different mechanism (Pavela, 2015). For the past two decades, numerous researches have been conducted on the biological activity of plant extracts against larvae of mosquitoes and insects, in that few plant extracts were commercialized. This shows that plant extracts were environmentally safe, non-toxicity against humans and other organisms (Govindarajan et al., 2016).

Extracts from plants may be alternative sources of mosquito control agents, since they constitute a rich source of bioactive compounds that are biodegradable into nontoxic products and potentially suitable for use to control mosquitoes. Plant extracts in general have been recognized as an important natural resource of insecticides. Phytochemicals derived from plant sources can act as larvicides, insect growth regulators, repellents, and oviposition attractants and can play an important role in the interruption of the transmission of mosquito-borne diseases at the individual as well as at the community level (Govindarajan et al., 2008a; 2008b).

Very few researches were published on the ethnobotanical study for the control of mosquitoborne diseases in Republic of Benin. Therefore, there is a need to carry out new researches for this purpose.

The goal of this research was to study the ethnobotany for malaria vector control in Couffo department in south-western Republic of Benin, West Africa.

Reference

Aïzoun N, Djèdatin G, Koukoui O, Chougourou D. 2022a. Larvicidal and repellent activities of ethanolic extract of Artemisia annua (Asteraceae) and Carica papaya linn (Caricaceae) leaves in malaria vector control in Dogbo district in south-western Benin, West Africa. European Journal of Pharmaceutical and Medical Research 9(9), 80-88.

Aïzoun N, Adjatin A, Koukoui O, Chougourou D. 2022b. Larvicidal activities of ethanolic extracts of Hyptis suaveolens Linn (Lamiaceae) and Azadirachta indica (Meliaceae) leaves and their phytochemical properties in malaria vector control in Dogbo district in South-western Benin, West Africa. Global Journal of Engineering and Technological Advances 12(02), 113–120. https://doi.org/10.30574/gjeta.2022.12.2.0143.

Aïzoun N, Adjatin A. 2023. Repellent activities of ethanolic extract of Hyptis suaveolens linn. (Lamiaceae) and Azadirachta indica (Meliaceae) leaves in malaria vector control in Dogbo district in south-western Benin, West Africa. European Journal of Biomedical and Pharmaceutical Sciences 10(9), 46-51.

Aïzoun N, Codjia S, Honvoh E, Chougourou D. 2025. Repellent activities of ethanolic extract of Cymbopogon citratus (Poaceae) and Ocimum basilicum L. (Lamiaceae) leaves in malaria vector control in Dogbo district in south-western Benin, West Africa. International Journal of Current Microbiology and Applied Sciences 14(01), 159-167.

Anyaele OO, Amusan AAS. 2003. Toxicity of  hexanoic extracts of Dennettiatripetala (G. Baxer) on larvae of Aedes aegypti (L.). African Journal of Biomedical Research 6, 49-53.

Govindarajan M, Jebanesan A, Pushpanathan T. 2008a. Larvicidal and ovicidal activity of  Cassia fistula Linn. leaf extract against filarial and malarial vector mosquitoes. Parasitology Research 102, 289-292. https://doi.org/10.1007/s00436-007-0761-y.

Govindarajan M, Jebanesan A, Pushpanathan T, Samidurai K. 2008b. Studies on effect of Acalypha indica  L. (Euphorbiaceae) leaf extracts on the malarial vector, Anopheles stephensi Liston (Diptera: Culicidae). Parasitology Research 103, 691-695. https://doi.org/10.1007/s00436-008-1032-2.

Govindarajan M, Rajeswary M, Bhattacharyya A, Benelli G. 2016. Eugenol, apinene and ß-caryophyllene from Plectranthusbarbatus essential oil as ecofriendly larvicides against malaria, dengue and Japanese encephalitis mosquito vectors. Parasitology Research 115(2), 807-815. https://doi.org/10.1007/s00436-015-4809-0.

Honvoh E, Aïzoun N, Adjatin A, Chougourou D. 2025. Comparison of larvicidal activities of ethanolic extract of six plants leaves in malaria vector control in Couffo department in south-western Benin, West Africa. European Journal of Biomedical and Pharmaceutical Sciences 12(1), 41-49.

Liang Y, Li Xiuwei, Zumin Gu Peiwen Qin, Ji Mingshan. 2015. Toxicity of amorphigenin from the seeds of Amorpha fruticosa against the larvae of Culex pipiens pallens (Diptera: Culicidae). Molecules 20, 3238–3254. https://doi.org/10.3390/molecules20023238

Pavela R. 2015. Acute toxicity and synergistic and antagonistic effects of the aromatic compounds of some essential oils against Culex quinquefasciatus Say larvae. Parasitology Research 114, 3835–3853. https://doi.org/10.1007/s00436-015-4614-9

WHO. World Malaria Report 2024. Geneva. World Heath Organization.

Article source : Ethnobotanical study for malaria vector control in Couffo department in south-western Republic ofBenin, West Africa 

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Hidden Toxicity of Femoral Orthopedic Implants | IJB 2026

Haroon Habib Beigh,  Nabeel Khan and Mirza Masroor Ali Beg, from the institute of the Kazakhstan. wrote a review paper about, Hidden Toxicity of Femoral Orthopedic Implants entitled, The hidden burden: A review of toxicity from femoral orthopedic implants. This research paper published by the International Journal of Biosciences | IJB. an open access scholarly research journal on Biosciences under the affiliation of the International Network For Natural Sciences | INNSpub. an open access multidisciplinary research journal publisher. 

Abstract

Locomotion is one of the essential characters of humans. During daily activity human body is subjected to several factors such as shock, stress, strain and other environmental factors. Most of times human body remains un-affected by these factors as they are contradicted by skin, fats, muscles, bones etc. But when the body is subjected to a trauma of higher impact an injury can occur which can affect capability of human body. One of the common injuries is bone fractures. Among the bone’s femur is susceptible to the fractures being the longest bone in the human body. Femoral fractures affect mobility of humans to the greater extent; in order to restore maximum function of femur, implants are used to treat fractures. Implants such as nails, Screws, plates are used to repair the bone. These implants are either made up of metals or alloys commonly used metals are titanium, gold, iron, cobalt, chromium and several others that have been reported to cause one or other toxicological episodes. Femoral fractures may take months to get treated and till the time implants are embedded in human body. Within this time frame implants start producing oxides that may result in several implications such as hypersensitivity, allergies, neurological problems and other toxicological implications. 

 

 Introduction

Femoral shaft fractures are a common orthopedic injury due to high impact trauma. The incidence of femoral shaft fracture ranges between 10 and 21 per 100,000 per year and out of these 2 percent are open fractures. The most common etiological factor is due to high or low energy mechanisms, most commonly caused by automobile accidents and falls from height. Low energy impact injuries are more common in elderly population suffering from osteoporosis (Ghouri et al., 2023). Common femoral factures are indicated in (Fig. 1).

There has been 1-9 % incidence of proximal femur fractures (femur head and neck and intertrochanteric) associated with femur shaft fractures and 20-50% of such associated fractures go unnoticed. Such associated fractures should be investigated thoroughly as they are clinically important for further management. Intramedullary nailing is the gold standard for the treatment of femoral shaft fractures. Along with the femoral shaft fractures, there is another type of femoral fracture closely associated with implants in their management. These are the femoral neck fractures which is a type of intra-capsular hip fracture. The femoral neck is the connection between the femoral head and the shaft; the head of femur articulates with the acetabulum therefore this junctional location makes the neck of femur prone to fractures. Results of annual census indicate that out of 1.6 million hip fractures annually, 70 percent of these fractures occur in women indicating a strong correlation between female gender and hip fractures (Osteoporosis Canada, 2021). Other risk factors include osteoporosis and decreased mobility. The management of such fractures depends on several factors such as Age, Displacement of fracture etc. Elderly patients with displaced fracture either undergo Hemiarthroplasty or Total hip arthroplasty depending upon their baseline activity level and age (Sansone et al., 2013).

Orthopedic implants are broadly divided into Permanent, including hip, knee, ankle, shoulder, elbow wrists and finger joints, and Temporary including wires, screws, plates and intra-medullary nails. Metallic alloys, ceramic and polymers are the principal compositional part of such implants (Ghouri et al., 2023; Al-Shalawi et al., 2023).

Titanium alloys are most commonly used in the production of orthopedic implants such as intramedullary nails and total hip femoral stem (Jacobs et al., 2001). The reason for this is that Titanium has the key properties desirable for any implanted material in the body, which is resistance to metabolism by the body and to the oxidative processes therefore not leading to production of any active metabolites. Titanium when used as an implant leads to form a thin oxidative film over the implant which is biologically inert. Stainless steel is also a component of choice in various implants and has been the earliest modern implant being used worldwide. The most commonly used alloy is 316L composed of iron, chromium, nickel and molybdenum. It’s generally used in making nails, screws and early generation intramedullary nails. Cobalt Chrome implants have also been widely used in total hip arthroplasties. It is a biological inert agent but these implants are avoided in patients with nickel allergy as it might cause metal hypersensitivity reaction (Tapscott and Wottowa, 2025).

Biocompatibility refers to how our body reacts and interacts with foreign matter. In terms of orthopedic implants, it implies how the implant will perform its function and the body has a non-pathological response to the specific implant. Majority of the implants made from stainless steel; titanium alloys and cobalt and chromium (Co-Cr) alloys have excellent biocompatibility due to their inert nature. Corrosion is also a significant factor when it comes to choosing the type of materials for implants as this process can lead to release of cytotoxic, allergenic and carcinogenic substances in the body (Al-Shalawi et al., 2023).

Chromium and Cobalt are a major component of orthopedic implants and they are also a component of several enzymes in our body. Their high doses especially Cobalt can have toxic effects on our body systems leading to several symptoms of neurological, cardiological, hematological and endocrinological nature. Cobalt (Co) toxicity can cause tinnitus, vertigo, deafness and convulsions, also it can lead to hypothyroidism, polycythemia and cardiomyopathies (Sansone et al., 2013). The incidence of such cases is low but literatures have put up case reports of Co-Cr toxicity after THR (Total Hip Replacement) surgeries. Cobalt toxicity in such cases can lead to anorexia, fatigue, auditory or ophthalmological damage (Samargandi et al., 2024).

Metal on metal configuration in hip arthroplasty significantly elevates serum Co and Cr level as several researches have indicated and this also correlated with the increase in the level of pain (Stołtny et al., 2023). There has been a case report on bilateral visual loss after multiple hip arthroplasties along with hypothyroidism and neuropathy. The patient’s Co serum level was found to be >1000 µg/L (normal range 0-0.9ng/mL). There was a decrease in visual acuity in both the eyes along with bilateral temporal optic disc pallor (Garcia et al., 2020). Aluminum toxicity can cause memory loss, gait disturbances and might lead to development of Amyotrophic Lateral Sclerosis. A metal-on-metal hip implant consisting of Co and Cr alloy have shown an unusual increased lymphocytic infiltration and plasma cell accumulation in the peri-prosthetic tissues as compared to other implants. In the case of hip arthroplasty with conventional implants there is no lymphocytic infiltration or plasma cells presence instead the inflammation is histiocytic predominant (Hallab et al., 2001).

Chronic accumulation of Aluminum in brain can lead to development of Alzheimer’s and Parkinson’s disease and in kidneys can cause fibrosis in the glomeruli and Bowman’s corpuscles (Peto, 2010; Ollivere et al., 2012). Several studies have suggested severe complications or toxicities associated with orthopedic implants or associated metals (Table 1).

Based on the type of femoral facture different set of implants can be used to modulate the fracture such as Femoral Head, Plates, Screws, Endoprosthetic Replacements, Femoral Stems and femoral Nails. Insertion and placement of implants can lead to emotional and economic distress along with discomfort in locomotion. Patients have to go for long term treatment after surgery and physiotherapy in order to walk properly.

Reference

Al-Elq AH. 2022. Osteoporosis in Saudi Arabia: Current and future perspectives. Saudi Medical Journal 43(2), 127–136.

Al-Shalawi FD, Mohamed Ariff AH, Jung DW, Mohd Ariffin MKA, Seng Kim CL, Brabazon D, Al-Osaimi MO. 2023. Biomaterials as implants in the orthopedic field for regenerative medicine: Metal versus synthetic polymers. Polymers 15(12), 2601. DOI: 10.3390/polym15122601.

Auckland District Health Board. 2019. Health needs assessment: Osteoporosis and fragility fractures. Auckland District Health Board.

Australian Institute of Health and Welfare (AIHW). 2023. Hip fracture incidence and hospitalisations. Australian Institute of Health and Welfare.

Bowsher JG, Hussain A, Williams PA, Shelton JC. 2006. Metal-on-metal hip simulator study of increased wear particle surface area due to severe patient activity. Proceedings of the Institution of Mechanical Engineers Part H 220, 279–287. DOI: 10.1243/09544119JEIM93.

Brauer CA, Coca-Perraillon M, Cutler DM, Rosen AB. 2009. Incidence and mortality of hip fractures in the United States. JAMA 302(14), 1573–1579.

Catelas I, Petit A, Zukor DJ, Antoniou J, Huk OL. 2003. TNF-alpha secretion and macrophage mortality induced by cobalt and chromium ions in vitro: Qualitative analysis of apoptosis. Biomaterials 24(3), 383–391. DOI: 10.1016/S0142-9612(02)00351-4.

Clark P, Atkinson EJ, O’Neill TW. 2019. The burden of osteoporosis in Latin America. Osteoporosis International 30(2), 259–266.

Clarke IC, Gustafson A. 2000. Clinical and hip simulator comparisons of ceramic-on-polyethylene and metal-on-polyethylene wear. Clinical Orthopaedics and Related Research 379, 34–40. DOI: 10.1097/00003086-200010000-00006.

Costa MD, Donner S, Bertrand J, Pop OL, Lohmann CH. 2023. Hypersensitivity and lymphocyte activation after total hip arthroplasty. Orthopädie 52(3), 214–221. DOI: 10.1007/s00132-023-04349-7.

Garcia MD, Hur M, Chen JJ, Bhatti MT. 2020. Cobalt toxic optic neuropathy and retinopathy: Case report and review of the literature. American Journal of Ophthalmology Case Reports 17, 100606. DOI: 10.1016/j.ajoc.2020.100606.

Gazzano E, Bracco P, Bistolfi A, Aldieri E, Ghigo D, Boffano M, Costa L, Brach Del Prever E. 2011. Ultra-high molecular weight polyethylene is cytotoxic and causes oxidative stress, even when modified. International Journal of Immunopathology and Pharmacology 24(1 Suppl. 2), 61–67. DOI: 10.1177/03946320110241S212.

Ghouri SI, Mustafa F, Kanbar A, Al Jogol H, Shunni A, Almadani A, Abdurraheim N, Goel AP, Abdelrahman H, Babikir E, Ramzee AF, Ahmed K, Alhardallo M, Asim M, Al-Thani H, El-Menyar A. 2023. Management of traumatic femur fractures: A focus on the time to intramedullary nailing and clinical outcomes. Diagnostics 13(6), 1147. DOI: 10.3390/diagnostics13061147.

Gill HS, Grammatopoulos G, Adshead S, Tsialogiannis E, Tsiridis E. 2012. Molecular and immune toxicity of CoCr nanoparticles in MoM hip arthroplasty. Trends in Molecular Medicine 18(3), 145–155. DOI: 10.1016/j.molmed.2011.12.002.

Glant TT, Jacobs JJ, Mikecz K, Yao J, Chubinskaja S, Williams JM, Urban RL, Shanbhag AS, Lee SH, Sumner DR. 1996. Particulate-induced, prostaglandin- and cytokine-mediated bone resorption in an experimental system and in failed joint replacements. American Journal of Therapeutics 3(1), 27–41. DOI: 10.1097/00045391-199601000-00006.

Hallab NJ, Mikecz K, Vermes C, Skipor A, Jacobs JJ. 2001. Orthopaedic implant related metal toxicity in terms of human lymphocyte reactivity to metal-protein complexes produced from cobalt-base and titanium-base implant alloy degradation. Molecular and Cellular Biochemistry 222(1–2), 127–136.

Hart AJ, Sabah SA, Bandi AS, Maggiore P, Tarassoli P, Sampson B, et al. 2021. Risk factors for adverse local tissue reactions following metal-on-metal hip arthroplasty. Bone & Joint Journal 103-B(6), 765–774.

Hasegawa M, Tone S, Naito Y, Wakabayashi H, Sudo A. 2024. Long-term results of hemi-resurfacing and metal-on-metal hip resurfacing for osteonecrosis of the femoral head. Journal of Artificial Organs 27(3), 277–283. DOI: 10.1007/s10047-023-01417-9.

He X, Reichl FX, Milz S, Michalke B, Wu X, Sprecher CM, Yang Y, Gahlert M, Röhling S, Kniha H, Hickel R, Högg C. 2020. Titanium and zirconium release from titanium- and zirconia implants in mini pig maxillae and their toxicity in vitro. Dental Materials 36(3), 402–412. DOI: 10.1016/j.dental.2020.01.013.

Jacobs JJ, Roebuck KA, Archibeck M, Hallab NJ, Glant TT. 2001. Osteolysis: Basic science. Clinical Orthopaedics and Related Research 393, 71–77. DOI: 10.1097/00003086-200112000-00008.

Judge A, Cooper C, Harvey NC, Javaid MK, Poole KE, et al. 2021. Modelling the epidemiology of hip fractures: A review of the literature. Osteoporosis International 32(6), 1027–1047.

Kanis JA, McCloskey EV, Johansson H, Cooper C, Rizzoli R. 2021. SCOPE 2021: A new scorecard for osteoporosis in Europe. Archives of Osteoporosis 16(1), 82.

Kasprzak KS. 2002. Oxidative DNA and protein damage in metal-induced toxicity and carcinogenesis. Free Radical Biology and Medicine 32(10), 958–967. DOI:10.1016/S0891-5849(02)00809-2.

Klein GL. 2019. Aluminum toxicity to bone: A multisystem effect? Osteoporosis and Sarcopenia 5(1), 2–5. DOI:10.1016/j.afos.2019.01.001.

Kurtz SM. 2020. Wear and corrosion in orthopedic implants. Acta Biomaterialia 113, 1–15.

Kwon YM, Lombardi AV, Jacobs JJ, Fehring TK, Lewis CG. 2022. Aseptic lymphocyte-dominated vasculitis-associated lesion (ALVAL) and metal hypersensitivity: Implications for hip arthroplasty. Bone & Joint Journal 104-B(9), 1003–1010.

Liu C, Li Y, Zhou Q, Chen H, Zhang H, Ling Z, Wang Z. 2025. Nano-TiO₂ inhibits cytotoxicity and osteogenic differentiation of CXCR4-transfected bone marrow mesenchymal stem cells. Pakistan Journal of Pharmaceutical Sciences 38(6), 2353–2360. DOI: 10.36721/PJPS.2025.38.6.REG.13359.1.

Magone K, Luckenbill D, Goswami T. 2015. Metal ions as inflammatory initiators of osteolysis. Archives of Orthopaedic and Trauma Surgery 135(5), 683–695. DOI: 10.1007/s00402-015-2196-8.

Matharu GS, Barlow BT, Hutt JR. 2021. Monitoring metal ion levels in patients with metal-on-metal hip implants: Guidance and outcomes. Bone & Joint Journal 103-B(2), 132–140.

Mithal A, Kaur P. 2018. Osteoporosis in India: A review of literature and resources. Indian Journal of Endocrinology and Metabolism 22(4), 449–454.

Ollivere B, Wimhurst JA, Clark IM, Donell ST. 2012. Current concepts in osteolysis. Journal of Bone and Joint Surgery British Volume 94(1), 10–15. DOI:10.1302/0301-620X.94B1.28047.

Osteoporosis Canada. 2021. The burden of osteoporosis in Canada. Osteoporosis Canada.

Oyinlola OE, Eke CB, Ogbonnaya U. 2020. Fragility fractures and orthopaedic healthcare in Nigeria: A call to action. Journal of Clinical Orthopaedics and Trauma 11(5), 731–735.

Peto MV. 2010. Aluminium and iron in humans: Bioaccumulation, pathology, and removal. Rejuvenation Research 13(5), 589–598. DOI:10.1089/rej.2009.0995.

Pinheiro MM, de Oliveira CM, Lebrão ML. 2020. Burden of osteoporosis in Brazil: A demographic analysis. Archives of Osteoporosis 15(1), 1–9.

Piscitelli P, Crea F, Fabiani A, Rizzo S. 2020. The burden of hip fractures in Italy: The EXTEND study. Bone 137, 115439.

Puleo DA, Huh WW. 1995. Acute toxicity of metal ions in cultures of osteogenic cells derived from bone marrow stromal cells. Journal of Applied Biomaterials 6(2), 109–116. DOI:10.1002/jab.770060205.

Rakow A, Schoon J, Dienelt A, John T, Textor M, Duda G, Perka C, Schulze F, Ode A. 2016. Influence of particulate and dissociated metal-on-metal hip endoprosthesis wear on mesenchymal stromal cells in vivo and in vitro. Biomaterials 98, 31–40. DOI:10.1016/j.biomaterials.2016.04.023.

Robert Koch Institute (RKI), Federal Statistical Office (DESTATIS). 2019. Health in Germany. Robert Koch Institute, Germany.

Rotstein A, Goldstein L, Goldstein R. 2022. Trends in hip fracture incidence and mortality in Israel. Israel Journal of Health Policy Research 11, 13.

Samargandi R, Le Nail LR, Hetaimish B, Saad M. 2024. Cobalt-chromium toxicity following revision of total hip replacement. Saudi Medical Journal 45(2), 194–198. DOI:10.15537/smj.2024.45.2.20230334.

Sansone V, Pagani D, Melato M. 2013. The effects on bone cells of metal ions released from orthopaedic implants: A review. Clinical Cases in Mineral and Bone Metabolism 10(1), 34–40. DOI: 10.11138/ccmbm/2013.10.1.034.

Schell LD, Lane WC, Coleman WE. 1968. The toxicity of polytetrafluoroethylene pyrolysis products including carbonyl fluoride and a reaction product, silicon tetrafluoride. American Industrial Hygiene Association Journal 29(1), 41–48. DOI: 10.1080/00028896809342979.

South African Bone Registry. South African Bone Registry.

Stołtny T, Dobrakowski M, Augustyn A. 2023. The concentration of chromium and cobalt ions and parameters of oxidative stress in serum and their impact on clinical outcomes after metaphyseal hip arthroplasty with modular metal heads. Journal of Orthopaedic Surgery and Research 18, 225. DOI: 10.1186/s13018-023-03618-7.

Tapscott DC, Wottowa C. 2025. Orthopedic implant materials. In: StatPearls. Treasure Island (FL): StatPearls Publishing.

Vermes C, Chandrasekaran R, Jacobs JJ, Galante JO, Roebuck KA, Glant TT. 2001. The effects of particulate wear debris, cytokines, and growth factors on the functions of MG-63 osteoblasts. Journal of Bone and Joint Surgery American Volume 83(2), 201–211. DOI: 10.2106/00004623-200102000-00007.

Wakabayashi H, Hasegawa M, Naito Y, Tone S, Sudo A. 2022. Minimum 10-year results of modular metal-on-metal total hip arthroplasty. Journal of Clinical Medicine 11(21), 6505. DOI: 10.3390/jcm11216505.

Wu D, Bhalekar RM, Marsh JS, Langton DJ, Stewart AJ. 2022. Periarticular metal hypersensitivity complications of hip bearings containing cobalt-chromium. EFORT Open Reviews 7(11), 758–771. DOI: 10.1530/EOR-22-0036.

Xia W, Wang Y, Zhang H, Kanis JA, Compston J. 2021. East meets West: A comprehensive view of osteoporosis epidemiology. Bone 144, 115830.

Yamamoto N, Yoshimura N, Ohtsuka M, Saita Y. 2021. Current status and projections of hip fracture in Japan. Journal of Orthopaedic Science 26(5), 745–749.

Yoon HK, Ha YC, Koo KH. 2021. Epidemiology of hip fracture in Korea: A nationwide cohort study. Journal of Bone Metabolism 28(3), 213–220.

Zeng Y, Feng W. 2013. Metal allergy in patients with total hip replacement: A review. Journal of International Medical Research 41(2), 247–252. DOI: 10.1177/0300060513476583.

Zhong Q, Pan X, Chen Y, Lian Q, Gao J, Xu Y, Wang J, Shi Z, Cheng H. 2024. Prosthetic metals: Release, metabolism and toxicity. International Journal of Nanomedicine 19, 5245–5267. DOI:10.2147/IJN.S459255.

Article source : The hidden burden: Areview of toxicity from femoral orthopedic implants   

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